Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1
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چکیده
منابع مشابه
Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. Despite intensive treatment, the prognosis for patients with GBM remains grim with a median survival of only 14.6 months. Immunotherapy has emerged as a promising approach for treating many cancers and affords the advantages of cellular-level specificity and the potential to generate durable immune su...
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Glioblastoma multiforme (GBM), a World Health Organization grade IV glioma, is the most common and aggressive primary brain tumor in humans. microRNAs (miRNAs) are aberrantly expressed in numerous cancer types, including GBM. Abnormally expressed miRNAs are commonly associated with malignant characteristics of GBM, including malignant growth, proliferation, apoptosis, invasion, metastasis and r...
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Financial Support: Gongda Xue and Debora Schmitz-Rohmer are supported by the Swiss 11 National Science Foundation SNF 31003A_130838 and 31003A_138287, respectively. Christian 12 Hundsrucker is supported by Swiss Initiative in Systems Biology (Systems Biology IT). 13 Alexander Hergovich is a Wellcome Trust Research Career Development fellow (grant 14 090090/Z/09/Z). The FMI is supported by the N...
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Plasma miRNAs have been reported as biomarkers for various diseases. In this study, we investigated whether plasma concentrations of miR-126 may be useful as biomarkers for laryngeal squamous cell carcinoma (LSCC). We examined the function and mechanism of miR-126 in LSCC by using cell biology and molecular pathology techniques such as western blotting, quantitative PCR, IHC and IF. The express...
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ژورنال
عنوان ژورنال: Nutrients
سال: 2019
ISSN: 2072-6643
DOI: 10.3390/nu11061343